- Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents.
Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents.
Bioorganic & medicinal chemistry letters (2002-09-10)
Masami Arai, Tamako Harasaki, Takashi Fukuoka, Satoru Kaneko, Toshiyuki Konosu
PMID12217365
ABSTRACT
N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-D-proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25-2 microg/mL.
MATERIALS