Functionalization of 6-nitrobenzo[1,3]dioxole with carbonyl compounds via TDAE methodology.

Functionalization of 6-nitrobenzo[1,3]dioxole with carbonyl compounds via TDAE methodology.

Molecules (Basel, Switzerland) (2007-11-17)

Ouassila Amiri-Attou, Thierry Terme, Patrice Vanelle

ABSTRACT

We report herein the synthesis of substituted 2-(6-nitrobenzo[1,3]dioxol-5-yl)-1- aryl ethanols and 2-(6-nitrobenzo[1,3]dioxol-5-yl)-propionic acid ethyl esters from the reaction of 5-chloromethyl-6-nitrobenzo[1,3]dioxole with various aromatic carbonyl and alpha- carbonyl ester derivatives using the tetrakis(dimethylamino)ethylene (TDAE) methodology.

MATERIALS

Product Number

Brand

Product Description

471453

Sigma-Aldrich

2-Dimethylaminoethanol, ≥99.5%

391263

Sigma-Aldrich

2-Dimethylaminoethanol, purified by redistillation, ≥99.5%

38990

Sigma-Aldrich

2-Dimethylaminoethanol, purum, ≥98.0% (GC)

07-4170

Sigma-Aldrich

2-Dimethylaminoethanol, SAJ first grade, ≥99.0%