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  • Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration.

Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration.

Chemical communications (Cambridge, England) (2010-05-13)
Karim Engelmark Cassimjee, Cecilia Branneby, Vahak Abedi, Andrew Wells, Per Berglund
ABSTRACT

Enantiopure chiral amines synthesis using omega-transaminases is hindered by an unfavourable equilibrium, but when using isopropylamine as the amine donor the equilibrium can be completely displaced by using a specific dehydrogenase in situ for removal of formed acetone.

MATERIALS
Product Number
Brand
Product Description

Supelco
Isopropylamine, anhydrous, analytical standard
Sigma-Aldrich
Isopropylamine, ≥99.5%