- Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.
Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.
Organic letters (2011-09-10)
Aditya Kulkarni, Weihong Zhou, Béla Török
PMID21902212
ABSTRACT
An environmentally benign procedure for the hydrogenation of unprotected indoles is described. The hydrogenation reaction is catalyzed by Pt/C and activated by p-toluenesulfonic acid in water as a solvent. The efficacy of the method is illustrated by the hydrogenation of a variety of substituted indoles to their corresponding indolines which were obtained in excellent yields.
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