- Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.
Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.
Chemical communications (Cambridge, England) (2012-01-24)
Xin Huang, Jin Peng, Lin Dong, Ying-Chun Chen
PMID22267122
ABSTRACT
The first organocatalytic asymmetric assembly of Morita-Baylis-Hillman carbonates of isatins and α-angelica lactone has been studied, affording multifunctional products containing two valuable pharmacophores and vicinal quaternary chiral centers in high stereoselectivity (up to 92% ee, dr >95:5).