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A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.

Chemical communications (Cambridge, England) (2012-09-27)
Haihua Xiao, Lesan Yan, Yu Zhang, Ruogu Qi, Wenliang Li, Rui Wang, Shi Liu, Yubin Huang, Yuxin Li, Xiabin Jing
ABSTRACT

A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
DCA Deblock (0.36M dichloroacetic acid in toluene)
Sigma-Aldrich
Dichloroacetic acid, ReagentPlus®, ≥99%