Investigations on acute hepato- and nephrotoxicity of pentabromophenol.

Pentabromophenol (PBP) was administered in a single or repeated doses to mice or in a single dose to rats. Slight changes were noted in the level of SGPT in mice serum and GSH in the liver, with a more pronounced increase of MDA after a single dose. Following repeated administration, gamma-GT and MDA were elevated. The nephrotoxic action of PBP in rats was manifested by the decreased of renal GSH levels, as well as by an increase in protein contents and the number of renal epithelial cells in urine. As a result, limited hepatotoxicity was found only in mice. The nephrotoxicity in rats was comparable with that for 2-bromophenol described earlier.