- Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Bioorganic & medicinal chemistry letters (2003-06-05)
Stefan Jaroch, Peter Hölscher, Hartmut Rehwinkel, Detlev Sülzle, Gerardine Burton, Margrit Hillmann, Fiona M McDonald
PMID12781178
ABSTRACT
Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.
MATERIALS