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  • Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives.

Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (1999-10-29)
G M Williams, M J Iatropoulos, J Whysner
ABSTRACT

Butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are widely used antioxidant food additives. They have been extensively studied for potential toxicities. This review details experimental studies of genotoxicity and carcinogenicity which bear on cancer hazard assessment of exposure to humans. We conclude that BHA and BHT pose no cancer hazard and, to the contrary, may be anticarcinogenic at current levels of food additive use.

MATERIALS
Product Number
Brand
Product Description

Supelco
3,5-Di-tert-butyl-4-hydroxytoluene, analytical standard
Supelco
Butylated Hydroxytoluene, Pharmaceutical Secondary Standard; Certified Reference Material
Butylhydroxytoluene, European Pharmacopoeia (EP) Reference Standard
USP
Butylated hydroxytoluene, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Butylated hydroxytoluene, ≥99%, FCC, FG
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2,6-Di-tert-butyl-4-methylphenol, SAJ first grade, ≥99.0%
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2,6-Di-tert-butyl-4-methylphenol, ≥99.0% (GC), powder
Sigma-Aldrich
Butylated hydroxyanisole, ≥98.5%
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2,6-Di-tert-butyl-4-methylphenol, purum, ≥99.0% (GC)
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, tested according to Ph. Eur.
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Butylated hydroxyanisole, 99%, FCC, FG
Supelco
Butylated hydroxyanisole, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Butylated hydroxyanisole, analytical standard