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Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.

Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.

Oncoimmunology (2015-09-26)

Xiaogang Wang, Haisheng Dong, Qi Li, Yingxian Li, An Hong

ABSTRACT

Metastatic melanoma is a highly aggressive cancer that is very difficult to treat. Additionally, the antitumor immune reaction of melanoma is still unclear. Here we demonstrate an association between the expression and secretion of the antioxidant protein thioredoxin (TRX) and increasing tumor stage and metastasis in melanoma. To elucidate the role of TRX in melanoma, we assessed the correlation of TRX expression with different disease parameters in melanoma. We also examined the

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

1,4-Dioxane, SAJ first grade

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Hydrogen peroxide solution, contains potassium stannate as inhibitor, 30-32 wt. % in water, semiconductor grade, 99.999% trace metals basis

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Ethanol, JIS first grade, 94.8-95.8%

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1,4-Dioxane, JIS special grade, ≥99.0%

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Ethanol, JIS special grade, 94.8-95.8%

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Hydrogen peroxide solution, SAJ first grade, ≥30.0%

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1,4-Dioxane, suitable for HPLC

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Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)

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Hydrogen peroxide solution, 30 % (w/w) in H₂O, contains stabilizer

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Hydrogen peroxide solution, 34.5-36.5%

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1,4-Dioxane, anhydrous, 99.8%, contains <=25 ppm BHT as stabilizer

Supelco

Ethanol standards 10% (v/v), 10 % (v/v) in H₂O, analytical standard

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Ethyl alcohol, Pure, 190 proof, meets USP testing specifications

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Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%

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Ethanol, JIS 1000, ≥99.5%, for residue analysis

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Ethanol, ≥99.5%

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9,10-Dihydroacridine, Aldrich^CPR