- Organocatalytic asymmetric direct alkylation of alpha-diazoester via C-H bond cleavage.
Organocatalytic asymmetric direct alkylation of alpha-diazoester via C-H bond cleavage.
Journal of the American Chemical Society (2005-06-30)
Daisuke Uraguchi, Keiichi Sorimachi, Masahiro Terada
PMID15984850
ABSTRACT
A new variant of phosphoric acid-catalyzed C-C bond forming reaction, direct alkylation of alpha-diazoester, via C-H bond cleavage is presented. The resulting products, beta-amino-alpha-diazoesters, are highly functionalized and useful synthetic precursors for various types of beta-amino acids.
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