- Antibacterial and antitumor macrolides from Streptomyces sp. Is9131.
Antibacterial and antitumor macrolides from Streptomyces sp. Is9131.
Archives of pharmacal research (2005-12-15)
Pei-Ji Zhao, Li-Ming Fan, Guo-Hong Li, Na Zhu, Yue-Mao Shen
PMID16350846
ABSTRACT
Four compounds, including two novel macrolides, were isolated from an endophyte Streptomyces sp. Is9131 of Maytenus hookeri. Spectral data indicated that these compounds were dimeric dinactin (1), dimeric nonactin (2), cyclo-homononactic acid (3), and cyclo-nonactic acid (4). Bioassay results showed that dimeric dinactin had strong antineoplastic activity and antibacterial activity.
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