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  • Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia.

Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia.

Glia (2017-07-08)
Cuilian Du, Yalong Wang, Feifan Zhang, Shuxin Yan, Yuan Guan, Xiaoli Gong, Ting Zhang, Xiuyu Cui, Xiaomin Wang, Claire Xi Zhang
ABSTRACT

Cytokine secretion and phagocytosis are key functions of activated microglia. However, the molecular mechanisms underlying their regulation in microglia remain largely unknown. Here, we report that synaptotagmin-11 (Syt11), a non-Ca