- Redefining thymus medulla specialization for central tolerance.
Redefining thymus medulla specialization for central tolerance.
The Journal of experimental medicine (2017-08-24)
Emilie J Cosway, Beth Lucas, Kieran D James, Sonia M Parnell, Manuela Carvalho-Gaspar, Andrea J White, Alexei V Tumanov, William E Jenkinson, Graham Anderson
PMID28830910
ABSTRACT
During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to its typical organized topology consisting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negative selection and Foxp3