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139181

Sigma-Aldrich

Bromodichloromethane

≥97%

Synonym(s):

Dichlorobromomethane

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About This Item

Linear Formula:
BrCHCl2
CAS Number:
75-27-4
Molecular Weight:
163.83
Beilstein/REAXYS Number:
1697005
EC Number:
200-856-7
MDL number:
MFCD00000824
UNSPSC Code:
12352100
PubChem Substance ID:
24848395

Quality Level

100

assay

≥97%

form

liquid

contains

potassium carbonate as stabilizer

refractive index

n20/D 1.497 (lit.)

bp

87 °C (lit.)

mp

−55 °C (lit.)

solubility

water: insoluble

density

1.98 g/mL at 25 °C (lit.)

SMILES string

ClC(Cl)Br

InChI

1S/CHBrCl2/c2-1(3)4/h1H

InChI key

FMWLUWPQPKEARP-UHFFFAOYSA-N

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Application

Bromodichloromethane was used to investigate the in vivo genotoxicity of chlorodibromomethane, bromodichloromethane and bromoform in mice.

Biochem/physiol Actions

Bromodichloromethane (BDCM) induces steatohepatitic injury in human liver. BDCM induces the cell proliferation in different tissues and kidney damage by renal tuble cell proliferation in male F344 rats.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chloroform

K J Stocker et al.
Mutagenesis, 12(3), 169-173 (1997-05-01)
Chlorination of drinking water results in the formation of chlorodibromomethane, bromodichloromethane and bromoform. These trihalomethanes have all shown evidence of genotoxicity in bacterial and mammalian cell systems in vitro and some evidence of carcinogenicity in rodents. Chlorodibromomethane and bromodichloromethane have
Suvarthi Das et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(12), G950-G963 (2013-10-26)
Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular mechanisms that link these important events in NASH remain unclear. In this study, we investigated the mechanistic role of purinergic
Ted Lock et al.
Archives of toxicology, 78(7), 410-417 (2004-05-14)
Male F344 rats exposed to bromodichloromethane (BDCM) by gavage at 50 or 100 mg/kg/day for 5 days a week for 28 days excreted large amounts of formic acid in their urine, which was accompanied by a change in urinary pH.
Regina Grazuleviciene et al.
Occupational and environmental medicine, 70(4), 274-282 (2013-02-14)
Congenital anomalies have been inconsistently associated with maternal crude estimated exposure to drinking water trihalomethane (THM). We investigated the relationship between individual THM uptake during the first trimester of pregnancy and congenital anomalies. We estimated maternal THM uptake for 3074
Teresa L Leavens et al.
Toxicological sciences : an official journal of the Society of Toxicology, 99(2), 432-445 (2007-07-28)
Exposure to bromodichloromethane (BDCM), one of the most prevalent disinfection byproducts in drinking water, can occur via ingestion of water and by dermal absorption and inhalation during activities such as bathing and showering. The objectives of this research were to
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