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236349

Sigma-Aldrich

Butyryl chloride

≥99%

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About This Item

Linear Formula:
CH3CH2CH2COCl
CAS Number:
Molecular Weight:
106.55
Beilstein/REAXYS Number:
605395
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.7 (vs air)

Quality Level

assay

≥99%

form

liquid

refractive index

n20/D 1.412 (lit.)

bp

102 °C (lit.)

mp

−89 °C (lit.)

solubility

diethyl ether: miscible(lit.)

density

1.026 g/mL at 25 °C (lit.)

SMILES string

CCCC(Cl)=O

InChI

1S/C4H7ClO/c1-2-3-4(5)6/h2-3H2,1H3

InChI key

DVECBJCOGJRVPX-UHFFFAOYSA-N

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General description

Photchlorination of butyryl chloride in liquid phase has been investigated.

Application

Butyryl chloride can be used as:
  • A reagent in the acylation of thiophene in the liquid phase catalyzed by zeolites.
  • A source of CO and -Cl in the chlorocarbonylation of aryl bromides to yield acid chlorides.
  • An intermediate in the synthesis of aryl [11C]methylsulfones for PET applications.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

wgk_germany

WGK 1

flash_point_f

64.4 °F

flash_point_c

18 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A lewis acid site-activated reaction in zeolites: thiophene acylation by butyryl chloride.
Isaev Y and Fripiat JJ.
J. Catal., 182(1), 257-263 (1999)
CHLORINATION OF BUTYRYL CHLORIDE IN THE LIQUID-PHASE.
Korhonen IO.
Acta Chemica Scandinavica. Series B, 35(3), 175-178 (1981)
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Majo VJ, et al.
Bioorganic & Medicinal Chemistry Letters, 15(19), 4268-4271 (2005)
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The influence of buffer type, co-solvent type, and acyl chain length was investigated for the enantioselective hydrolysis of racemic 4-arylbut-3-en-2-yl esters using Lecitase™ Ultra (LU). Immobilized preparations of the Lecitase™ Ultra enzyme had significantly higher activity and enantioselectivity than the
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2-Hydroxy-2-(ethoxyphenylphosphinyl)acetic acid, a new type of organophosphorus compound possessing two stereogenic centers, was investigated. Racemic 2-butyryloxy-2-(ethoxyphenylphosphinyl)acetic acid was synthesized and hydrolyzed using four bacterial species as biocatalysts. In all cases the reaction was more or less stereoselective and isomers bearing

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