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240176

Sigma-Aldrich

DL-Malic acid

ReagentPlus®, ≥99%

Synonym(s):

(±)-2-Hydroxysuccinic acid, DL-Hydroxybutanedioic acid

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About This Item

Linear Formula:
HO2CCH2CH(OH)CO2H
CAS Number:
Molecular Weight:
134.09
Beilstein/REAXYS Number:
1723539
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

vapor density

4.6 (vs air)

Quality Level

vapor pressure

<0.1 mmHg ( 20 °C)

product line

ReagentPlus®

assay

≥99%

form

solid

autoignition temp.

644 °F

mp

131-133 °C (lit.)

solubility

acetone: soluble 17.75g/100g at 20 °C(lit.)
diethyl ether: soluble 0.84g/100g at 20 °C(lit.)
dioxane: soluble 22.7 g/100g at 20 °C(lit.)
ethanol: soluble 45.53g/100g at 20 °C(lit.)
methanol: soluble 82.7 g/100g at 20 °C(lit.)
water: soluble 55.8g/100g at 20 °C(lit.)
benzene: insoluble(lit.)

SMILES string

OC(CC(O)=O)C(O)=O

InChI

1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)

InChI key

BJEPYKJPYRNKOW-UHFFFAOYSA-N

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General description

The chiral resolution of DL-malic acid by ligand-exchange capillary electrophoresis was studied.

Application

DL-Malic acid (MA) can be used:
  • As a dopant in the ammonium dihydrogen phosphate (ADP) crystal to improve the properties of ADP crystals.
  • To form a water-soluble complex, Nb-MA which can further react with LiCl to form lithium niobate (LiNbO3) powders.
  • As a monomer to synthesize a co-polymer, poly(DL-lactic acid-co-α,β-malic acid) (PLMA) with DL-lactic acid which can be coated over magnetic Fe3O4 nanoparticles after functionalizing with fluorescein isothiocyanate (FITC), to be used as a MRI T2-contrast agent.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

397.4 °F

flash_point_c

203 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Kodama et al.
Electrophoresis, 22(15), 3286-3290 (2001-10-09)
Chiral resolution of native DL-malic acid was achieved by ligand-exchange capillary electrophoresis using copper(II)-L-tartrate as a chiral selector. Factors affecting chiral resolution, migration time, and peak area of malic acid were studied. The running conditions for optimum separation of malic
Chemical synthesis of lithium niobate powders (LiNbO3) prepared from water-soluble DL-malic acid complexes
Camargo ER and Kakihana M
Chemistry of Materials, 13(5), 1905-1909 (2001)
Growth of DL-malic acid-doped ammonium dihydrogen phosphate crystal and its characterization
Rajesh P and Ramasamy P
Journal of Crystal Growth, 311(13), 3491-3497 (2009)
Biodegradable magnetic-fluorescent magnetite/poly (DL-lactic acid-co-?, ?-malic acid) composite nanoparticles for stem cell labeling
Wang L, et al.
Biomaterials, 31(13), 3502-3511 (2010)
G Anneroth et al.
Scandinavian journal of dental research, 88(3), 214-218 (1980-06-01)
Two saliva stimulating drugs, solutions of Hybrin and malic acid were in an in vitro study found to have a heavy demineralizing effect on the root surface of the dental hard tissue. Consequently the drugs cannot be recommended to patients

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