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283320

Sigma-Aldrich

Butyl lactate

98%

Synonym(s):

α-Hydroxypropionic acid butyl ester, (±)-n-Butyl lactate, 2-Hydroxypropanoic acid butyl ester, Butyl α-hydroxypropionate, Butyl 2-hydroxypropanoate, n-Butyl lactate

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About This Item

Linear Formula:
CH3CH(OH)CO2(CH2)3CH3
CAS Number:
138-22-7
Molecular Weight:
146.18
EC Number:
205-316-4
MDL number:
MFCD00004519
UNSPSC Code:
12352100
PubChem Substance ID:
24857101
NACRES:
NA.22

vapor density

5.04 (vs air)

Quality Level

200

vapor pressure

0.4 mmHg ( 20 °C)

assay

98%

form

liquid

refractive index

n20/D 1.421 (lit.)

bp

185-187 °C (lit.)

mp

−28 °C (lit.)

density

0.984 g/mL at 25 °C (lit.)

SMILES string

CCCCOC(=O)C(C)O

InChI

1S/C7H14O3/c1-3-4-5-10-7(9)6(2)8/h6,8H,3-5H2,1-2H3

InChI key

MRABAEUHTLLEML-UHFFFAOYSA-N

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Application

Butyl lactate has been used:
  • in the preparation of solid lipid nanoparticles by a solvent emulsification–diffusion technique
  • in the synthesis of nanoparticles of griseofulvin from water dilutable microemulsions by the solvent diffusion technique
  • as cosurfactant on the preparation of microemulsions with anionic surfactant

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

156.2 °F - closed cup

flash_point_c

69 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Microemulsions with butyl lactate as cosurfactant.
<BIG>Comelles F and Pascual A. </BIG>
Journal of Dispersion Science and Technology, 18(2), 161-175 (1997)
Michele Trotta et al.
International journal of pharmaceutics, 257(1-2), 153-160 (2003-04-25)
A preparation method for nanoparticles based on the emulsification of a butyl lactate or benzyl alcohol solution of a solid lipid in an aqueous solution of different emulsifiers, followed by dilution of the emulsion with water, was used to prepare
Hitomi Ohara et al.
Journal of bioscience and bioengineering, 111(1), 19-21 (2010-09-21)
n-Butyl D- and L-lactates (BuDLa and BuLLa) were incubated with immobilized lipase. (1)H-NMR showed that BuDLa reacted to oligomers, while BuLLa did not react. A mixture containing 90.4% of BuLLa and 9.6% of BuDLa was incubated with the enzyme for
Domenico Pirozzi et al.
Biotechnology progress, 22(2), 444-448 (2006-04-08)
The alpha-hydroxy esters are increasingly employed in cosmetic, food, and pharmaceutical formulations as they determine reduced skin-irritant effects in comparison with the respective acids, offering similar hygroscopic, emulsifying, and exfoliating properties. The enzymatic synthesis of lactate esters in nonaqueous systems
Michele Trotta et al.
International journal of pharmaceutics, 254(2), 235-242 (2003-03-08)
Nanoparticles of griseofulvin, a model drug with poor solubility and low bioavailability, were prepared from water dilutable microemulsions by the solvent diffusion technique. Solvent-in-water microemulsion formulations containing water, butyl lactate, lecithin, taurodeoxycholate sodium salt (TDC) or dipotassium glycyrrhizinate (KG), 1,2-propanediol
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