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Sigma-Aldrich

1-(2-Hydroxyethyl)-2-pyrrolidone

98%

Synonym(s):

1-(β-Hydroxyethyl)-2-pyrrolidone, 1-(2-Hydroxyethyl)-2-oxopyrrolidine, 2-(2-Oxopyrrolidin-1-yl)ethanol, 2-Hydroxyethylpyrrolidin-2-one, N-(β-Hydroxyethyl)-2-pyrrolidinone, N-(2-Hydroxyethyl)-2-pyrrolidinone

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About This Item

Empirical Formula (Hill Notation):
C6H11NO2
CAS Number:
3445-11-2
Molecular Weight:
129.16
Beilstein/REAXYS Number:
112181
EC Number:
222-359-4
MDL number:
MFCD00014103
UNSPSC Code:
12352100
PubChem Substance ID:
24859862
NACRES:
NA.22

Quality Level

200

assay

98%

form

liquid

refractive index

n20/D 1.496 (lit.)

bp

140-142 °C/3 mmHg (lit.)

density

1.143 g/mL at 25 °C (lit.)

SMILES string

OCCN1CCCC1=O

InChI

1S/C6H11NO2/c8-5-4-7-3-1-2-6(7)9/h8H,1-5H2

InChI key

WDQFELCEOPFLCZ-UHFFFAOYSA-N

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General description

1-(2-Hydroxyethyl)-2-pyrrolidone serves as a versatile heterocyclic building block in the synthesis of pharmaceutical compounds.

Application

1-(2-Hydroxyethyl)-2-pyrrolidone (HEP) can be used as a starting material for the preparation of chemical intermediates such as 1-vinylpyrrolidinone , 1-[2-(diethylamino)ethyl]-2-pyrrolidinone , 1-(2-bromoethyl)-2-pyrrolidinone.
It can also be used as a building block in the synthesis of hexakis[2-(2-oxo-1-pyrrolidinyl)ethoxy]cyclotriphosphazene by a nucleophilic substitution reaction with hexachlorocyclotriphosphazene.
1-(2-Hydroxyethyl)-2-pyrrolidone may be used in chemical synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 2

flash_point_f

closed cup

flash_point_c

closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis and Characterization of Hexakis [2-(2-oxo-1-pyrrolidinyl) Cyclotriphosphazene][J]
Yuefan Y, et al.
Chemistry (Weinheim An Der Bergstrasse, Germany), 7(6), 472-476 (2007)
Synthesis and radioprotective properties of some 2-pyrrolidone derivatives
Lisina NI, et al.
Pharmaceutical Chemistry Journal, 22(6), 472-476 (1988)
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Andrushko N, et al.
ChemCatChem, 2(6), 640-643 (2010)
Development of a new production process for N-vinyl-2-pyrrolidone
Shimasaki Y, et al.
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Matthew J Lacey et al.
ChemSusChem, 10(13), 2758-2766 (2017-05-26)
We report here a water-based functional binder framework for the lithium-sulfur battery systems, based on the general combination of a polyether and an amide-containing polymer. These binders are applied to positive electrodes optimised towards high-energy electrochemical performance based only on

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