396265
Bis(2-carboxyethylgermanium(IV) sesquioxide)
99%
Synonym(s):
GE 132
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About This Item
Linear Formula:
O[Ge(=O)CH2CH2CO2H]2
CAS Number:
Molecular Weight:
339.42
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
assay
99%
form
solid
SMILES string
OC(=O)CC[Ge](=O)O[Ge](=O)CCC(O)=O
InChI
1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)
InChI key
XEABSBMNTNXEJM-UHFFFAOYSA-N
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General description
Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.
Application
Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications.
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Petra Mulder et al.
PloS one, 12(1), e0169740-e0169740 (2017-01-12)
Obese patients with chronic inflammation in white adipose tissue (WAT) have an increased risk of developing non-alcoholic steatohepatitis (NASH). The C-C chemokine receptor-2 (CCR2) has a crucial role in the recruitment of immune cells to WAT and liver, thereby promoting
Bonnie J Kaplan et al.
Journal of alternative and complementary medicine (New York, N.Y.), 10(2), 337-344 (2004-05-29)
This paper reviews the history, chemistry, safety, toxicity, and anticancer effects of the organogermanium compound bis (2-carboxyethylgermanium) sesquioxide (CEGS). A companion review follows, discussing the inaccuracies in the scientific record that have prematurely terminated research on clinical uses of CEGS.
Takashi Nakamura et al.
Bioscience, biotechnology, and biochemistry, 76(2), 375-377 (2012-02-09)
The organic germanium compound, Ge-132, has immune-modulating effects. We evaluated the symbiotic effects of Ge-132 with lactobacilli and oligosaccharide (LB/OS) on the immune responses of mice. The highest fecal IgA levels were observed in the mice receiving a low concentration
Yasuhiro Eto et al.
Journal of cardiovascular pharmacology, 41(2), 171-177 (2003-01-28)
Macrophages play an important role in the pathogenesis of atherosclerosis, for which monocyte chemoattractant protein (MCP)-1 and CCR2 chemokine receptors may be involved. The authors have recently demonstrated that propagermanium exerts inhibitory effect on the CCR2 receptors. In the current
Yun Huan Yuan et al.
Nanoscale, 7(40), 16841-16847 (2015-09-26)
Carbon dots doped with germanium (GeCDs) were firstly prepared by a new simple 15 min carbonation synthesis route, exhibiting excitation-independent photoluminescence (PL), which could avoid autofluorescence in bioimaging applications. The as-prepared GeCDs have low cell toxicity, good biocompatibility, high intracellular
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