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481505

Sigma-Aldrich

Sulfamic acid

99.999% trace metals basis

Synonym(s):

Amidosulfonic acid

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About This Item

Linear Formula:
NH2SO3H
CAS Number:
5329-14-6
Molecular Weight:
97.09
EC Number:
226-218-8
MDL number:
MFCD00011603
UNSPSC Code:
12352301
PubChem Substance ID:
24871761
NACRES:
NA.22

Quality Level

100

assay

99.999% trace metals basis

form

crystals

mp

215-225 °C (dec.) (lit.)

density

2.151 g/cm3 at 25 °C

anion traces

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.05%

cation traces

Fe: ≤5 ppm
heavy metals (as Pb): ≤0.001%

SMILES string

NS(O)(=O)=O

InChI

1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4)

InChI key

IIACRCGMVDHOTQ-UHFFFAOYSA-N

Gene Information

human ... CA1(759) , CA2(760)

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General description

Sulfamic acid, the monoamide of sulfuric acid, is a strong inorganic acid. It is generally used in chemical cleaning processes like removal of nitrites, carbonate- and phosphate-containing deposits. It is used as a raw material for the preparation of a synthetic sweetener i.e, sodium cyclohexylsulfamate.

Sulfamic acid is an amino acid with sulfur and is mildly acidic. It acts as a green catalyst in the esterification reaction.

Application

Sulfamic acid can be used as a catalyst in:
  • Friedlander quinoline synthesis.
  • Liquid Beckmann rearrangement for the synthesis of amides from ketoximes.
  • The preparation of α-aminophosphonates via a three-component reaction between aldehydes, amines, and diethyl phosphite.

Features and Benefits

Meets A.C.S. reagent specifications.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

8B - Non-combustible, corrosive hazardous materials

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sulfamic Acid and Sulfamates
Kirk-Othmer Encyclopedia of Chemical Technology (2000)
Yoshikubo K, et al.
Yoshikubo K and suzuki M, Kirk-Othmer Encyclopedia of Chemical Technology null
Sulfamic acid
Ullmann's Encyclopedia of Industrial Chemistry (2000)
Sulfamic acid: an efficient, cost-effective and recyclable solid acid catalyst for the Friedlander quinoline synthesis
Yadav JS, et al.
Tetrahedron Letters, 46(42), 7249-7253 (2005)
Jean-Yves Winum et al.
Bioorganic & medicinal chemistry, 21(6), 1419-1426 (2012-12-04)
Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with the help of X-ray crystallography, much
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