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Sigma-Aldrich

Nickel(II) chloride hexahydrate

99.9% trace metals basis

Synonym(s):

Nickel chloride hexahydrate 2, Nickel dichloride hexahydrate

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About This Item

Linear Formula:
NiCl2 · 6H2O
CAS Number:
Molecular Weight:
237.69
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.23

Quality Level

assay

99.9% trace metals basis

form

solid

impurities

≤1500.0 ppm Trace Metal Analysis

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl[Ni]Cl

InChI

1S/2ClH.Ni.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

InChI key

LAIZPRYFQUWUBN-UHFFFAOYSA-L

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General description

Nickel(II) chloride hexahydrate is a nickel salt that can be used as a catalyst. It is cost effective and can be used in a variety of industrial processes. It can also be used in cross-coupling reactions.

Application


  • Dihydrocodeine-D₆ hydrochloride in bioequivalence studies: A sensitive and rapid HPLC-MS method utilizing Dihydrocodeine-D₆ hydrochloride as a stable isotope-labeled internal standard was developed, demonstrating its critical role in pharmacokinetic and bioequivalence research. This application supports drug development processes, especially for opioid-related therapeutics, ensuring the precision and reliability of bioanalytical assays (Zhu et al., 2022).

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

target_organs

Lungs

Storage Class

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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NiCl2.6H2O: an efficient catalyst precursor for phosphine-free Heck and Sonogashira cross-coupling reactions
Nowrouzi N and Zarei M
Tetrahedron, 71(41), 7847-7852 (2015)
Kariana Moreno-Sader et al.
ACS omega, 4(6), 10834-10844 (2019-08-29)
Nanocomposites composed of polyacrylamide and nanoclay were synthesized via free-radical cross-linking polymerization and used to adsorb Co2+ and Ni2+ ions from water. The polyacrylamide (PAM)/sodium montmorillonite (Na-MMT) nanocomposites were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron
Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel (II) chloride hexahydrate catalyzed one-pot four-component reaction.
Khan AT, et al.
Tetrahedron Letters, 53(32), 4145-4150 (2012)
John M Besser et al.
Environmental toxicology and chemistry, 32(11), 2495-2506 (2013-05-10)
This study evaluated the chronic toxicity of Ni-spiked freshwater sediments to benthic invertebrates. A 2-step spiking procedure (spiking and sediment dilution) and a 2-stage equilibration period (10 wk anaerobic and 1 wk aerobic) were used to spike 8 freshwater sediments with wide
William G Brumbaugh et al.
Environmental toxicology and chemistry, 32(11), 2482-2494 (2013-05-10)
Two spiking methods were compared and nickel (Ni) partitioning was evaluated during a series of toxicity tests with 8 different freshwater sediments having a range of physicochemical characteristics. A 2-step spiking approach with immediate pH adjustment by addition of NaOH

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