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1,3-Bis(4-carboxyphenoxy)propane

97%

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About This Item

Empirical Formula (Hill Notation):
C17H16O6
CAS Number:
3753-81-9
Molecular Weight:
316.31
MDL number:
MFCD00089995
UNSPSC Code:
12352100
PubChem Substance ID:
24884111
NACRES:
NA.22

Quality Level

100

assay

97%

form

solid

mp

310 °C (lit.)

SMILES string

OC(=O)c1ccc(OCCCOc2ccc(cc2)C(O)=O)cc1

InChI

1S/C17H16O6/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H,18,19)(H,20,21)

InChI key

VBISQLWPGDULSX-UHFFFAOYSA-N

Related Categories

Application

Building block for polyanhydrides, a class of bioerodible polymer with drug delivery applications.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H317,H400

Hazard Classifications

Aquatic Acute 1 - Skin Sens. 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

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A J Domb et al.
Biomaterials, 15(9), 681-688 (1994-07-01)
The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxy-phenoxypropane):sebacic acid] 20:80 [P(CPP:Sa)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA.
Xiaohua Liu et al.
Biomaterials, 28(28), 4124-4131 (2007-06-20)
Intermittent (pulsatile) administration of parathyroid hormone (PTH) is known to improve bone micro-architecture, mineral density and strength. Therefore, daily injection of PTH has been clinically used for the treatment of osteoporosis. However, this regimen of administration is not convenient and
Moon Suk Kim et al.
Bio-medical materials and engineering, 15(3), 229-238 (2005-05-25)
p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a
A D'Emanuele et al.
Pharmaceutical research, 9(10), 1279-1283 (1992-10-01)
We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis(p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the
Sijian Hou et al.
Macromolecular bioscience, 7(5), 620-628 (2007-04-26)
To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content.
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