Skip to Content
MilliporeSigma
All Photos(1)

Documents

759317

Sigma-Aldrich

4,4,4,4′,4′,4′-Hexafluoro-DL-valine

97%

Synonym(s):

2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric acid, 4,4,4,5,5,5-Hexafluoro-DL-valine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(CF3)2CHCH(NH2)COOH
CAS Number:
16063-80-2
Molecular Weight:
225.09
Beilstein/REAXYS Number:
2416649
EC Number:
240-207-5
MDL number:
MFCD00014349
UNSPSC Code:
12352100
PubChem Substance ID:
329766772
NACRES:
NA.22

Quality Level

100

assay

97%

form

crystals

mp

196-217 °C

application(s)

peptide synthesis

SMILES string

NC(C(C(F)(F)F)C(F)(F)F)C(O)=O

InChI

1S/C5H5F6NO2/c6-4(7,8)2(5(9,10)11)1(12)3(13)14/h1-2H,12H2,(H,13,14)

InChI key

KRNSHCKTGFAMPQ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

W H Vine et al.
Journal of medicinal chemistry, 24(9), 1043-1047 (1981-09-01)
Gamma, gammma, gammma, gammma', gamma', gammma'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis. Hexafluorovaline derivatives showed general resistance toward various enzymatic digestions and the tendency to racemize extensively upon carboxyl
K H Hsieh et al.
Journal of medicinal chemistry, 30(6), 1097-1100 (1987-06-01)
An improved synthesis of hexafluorovaline (Hfv) derivatives, i.e., DL-Hfv-OBzl and Boc-DL-Hfv, is described. Incorporation of hexafluorovaline into angiotensin resulted in [Sar1,Hfv8]AII and [Sar1,D-Hfv8]AII. At the nanogram/milliliter dose range, the L congener was 20-100 times more active as either angiotensin agonist

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service