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765309

Sigma-Aldrich

Gold nanoparticles

10 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Synonym(s):

Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

material

PEG 5000

Quality Level

100

form

dispersion in H2O
nanoparticles

packaging

glass bottle of 1 mL

OD

50

diameter

10 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

520 nm

functional group

amine

storage temp.

2-8°C

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General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

Application

Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may be used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
  • AuNPs may also be used in photothermal therapy and radiotherapy
  • Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
  • They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.

Features and Benefits

  • A negatively charged siRNA-PEG complex, attached to positively charged GNPs, is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
  • The PEG coating decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Gold nanoparticles 2-4 nm avg. part. size (TEM), octanethiol functionalized, 2 % (w/v) in toluene

Sigma-Aldrich

660426

Gold nanoparticles

Sarah D Brown et al.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of
Scott H Brewer et al.
Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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