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907251

Sigma-Aldrich

H-L-Photo-lysine HCl

≥98%

Synonym(s):

(S)-2-Amino-6-((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonylamino)hexanoic acid hydrochloride, (S)-2-Amino-6-((2-(3H-diazirin-3-yl)propoxy)carbonylamino)hexanoic acid hydrochloride, 3′-Azibutyl-N-carbamoyl-lysine hydrochloride, Abk, Diazirine amino acid, Photo-Lys, Photo-crosslinking amino acid, Photoprobe building block

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About This Item

Empirical Formula (Hill Notation):
C11H21ClN4O4
CAS Number:
1253643-88-7
Molecular Weight:
308.76
UNSPSC Code:
12352209

assay

≥98%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

availability

available only in USA

application(s)

peptide synthesis

storage temp.

−20°C

InChI

1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1

InChI key

LUCMNTLJAFTFDU-QMMMGPOBSA-N

Related Categories

Application

H-L-Photo-lysine HCl is a diazirine-containing lysine amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907383.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking</A

Genetic code expansion for multiprotein complex engineering

Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells

Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

related product

Product No.
Description
Pricing

96885

Z-Lys(Z)-OSu, ≥95.0% (HPLC)

55788

Nα-Fmoc-Nε-Dabcyl-L-lysine, technical, ≥90% (HPLC)

73749

Nα-Fmoc-Nε-biotinyl-L-lysine, ≥95.0% (HPLC)

F4061

Fmoc-Lys(Mca)-OH

900751

Biotinylated-D-lysine TFA salt

907294

Fmoc-L-Photo-Phe-OH, ≥95%

907324

Fmoc-L-photo-proline, ≥95%

907251

H-L-Photo-lysine HCl, ≥98%

907278

H-L-Photo-leucine HCl, ≥98%

907286

H-L-Photo-Proline hydrochloride, ≥95%

907340

H-L-Photo-Phe-OH, ≥98%

907367

Fmoc-L-photo-methionine, ≥95%

907375

H-L-Photo-methionine HCl, ≥95%

907383

Fmoc-L-Photo-Lysine, ≥95%

907391

Fmoc-L-photo-leucine, ≥98%

8.52097

Fmoc-Lys(biotin)-OH, Novabiochem®

8.52096

Fmoc-Lys(Dabcyl)-OH, Novabiochem®

8.52326

Fmoc-azidolysine, Novabiochem®

8.52095

Fmoc-Lys(Mca)-OH, Novabiochem®

8.52100

Fmoc-Lys(biotinyl-ε-aminocaproyl)-OH, Novabiochem®

8.52099

Fmoc-Lys(Dnp)-OH, Novabiochem®

914339

Fmoc-L-Lys(Nvoc)-OH, ≥98%

914088

N6-((2-Azidoethoxy)carbonyl)-L-lysine hydrochloride, ≥95%

914827

N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride, ≥98%

915793

Methyl-o-nitropiperonyllysine, ≥95%

pictograms

Flame
GHS02

signalword

Danger

hcodes

H242

Hazard Classifications

Self-react. C

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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