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908525

Sigma-Aldrich

Poly(D,L-lactide-b-glycolide) lactide:glycolide 75:25

amine (dihydrazide) terminated, average Mn 12,000

Synonym(s):

Amino-PLGA, Amino-functionalized PLGA, AminoPLGA, NH2 PLGA, PLGA-NH2

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About This Item

Linear Formula:
C2H7N2(C3H4O2)x(C2H2O2)yH
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder or chunks

feed ratio

lactide:glycolide 75:25

mol wt

average Mn 12,000

color

white to tan

storage temp.

−20°C

Related Categories

Application

Biocompatible and biodegradable polymer can be used in the formation of nanoparticles for drug delivery. The amine functional group on the chain end enables rapid and facile surface functionalization, allowing for this material to be used in applications such as targeted drug delivery.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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