910058
2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid
≥95%
Synonym(s):
2-2-6 PROTAC® linker, Alkyne-PEG2-acid, Bifunctional linker
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About This Item
Empirical Formula (Hill Notation):
C12H20O4
Molecular Weight:
228.28
UNSPSC Code:
12352106
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assay
≥95%
form
(Viscous Liquid or Semi-solid or Paste or Solid)
reaction suitability
reaction type: click chemistry
reagent type: linker
functional group
alkyne
carboxylic acid
storage temp.
2-8°C
SMILES string
OC(COCCOCCCCCCC#C)=O
Application
This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG2-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
Product No.
Description
Pricing
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Ashton C Lai et al.
Angewandte Chemie (International ed. in English), 55(2), 807-810 (2015-11-26)
Proteolysis Targeting Chimera (PROTAC) technology is a rapidly emerging alternative therapeutic strategy with the potential to address many of the challenges currently faced in modern drug development programs. PROTAC technology employs small molecules that recruit target proteins for ubiquitination and
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