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914770

Sigma-Aldrich

Diethyl-4-((3r,5r,7r)-adamantan-1-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

≥95%

Synonym(s):

4-Alkyl-1,4-dihydropyridine reagent, DHP reagent for light-mediated His modification

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About This Item

Empirical Formula (Hill Notation):
C23H33NO4
CAS Number:
Molecular Weight:
387.51
UNSPSC Code:
12352200

assay

≥95%

form

powder

storage temp.

−20°C

Application

Diethyl-4-((3r,5r,7r)-adamantan-1-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate was reported to chemoselectively modify histidine under visible light where the unsubstituted nitrogen groups on the modified His imidazole are conserved.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Xiaoping Chen et al.
Journal of the American Chemical Society, 141(45), 18230-18237 (2019-10-23)
Histidine (His) carries a unique heteroaromatic imidazole side chain and plays irreplaceable functional roles in peptides and proteins. Existing strategies for site-selective histidine modification predominantly rely on the N-substitution reactions of the moderately nucleophilic imidazole group, which inherently suffers from

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