Droplet generator chip - One channel design

Microfluidic generation of droplets can produce highly monodispersed droplets with high frequency (up to hundreds of kHz). Interest in droplet-based microfluidic systems has grown substantially, because microfluidics offers the ability to handle very small volumes (μl to fl) of fluids, provides better mixing, encapsulation, sorting, and sensing. Microfluidics can be used for high throughput experimentation. Microfluidic-based droplets have many applications, including micro and nanoparticle synthesis and chemical analysis. Highly controlled droplet production also makes single cell analysis, or drug testing possible.

Droplet generator chip - One channel design, Fluidic 162, COC is made of COC (Cyclic olefin copolymer), it features a double channel crossing in the droplet generation region and one droplet collection channel. Like most droplet generators with a double cross geometry, Fluidic 162 can also be used for single cross experiments by simply not connecting respective channels but closing their interfaces with plugs. With a nozzle size of 70 μm droplet sizes between 80 μm (∼260 pl) and 210 μm diameter can be realized. A constant droplet size can be generated in various flow speeds by preserving the oil to aqueous phase ratio. By increasing the oil phase flow rate at a constant aqueous flow rate, the droplet size can be varied.