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Sigma-Aldrich

Poly(ethylene glycol)-block-Poly(2-methacryloyloxyethyl phosphorylcholine)

PEG average Mn 5000,

PMPC Mn 21,000

Synonym(s):

PEG-b-PMPC, PEG-PMPC

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About This Item

Linear Formula:
CH3(C2H4O)nC6H7O2N(C11H22O6NP)
UNSPSC Code:
12352112
NACRES:
NA.23

Quality Level

100

form

powder

mol wt

PEG average Mn 5000

color

white

Related Categories

Application

PEG-b-PMPC is a biocompatible, non-fouling block copolymer composed of a neutral PEG block and a zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) block.


Poly (2-Methacryloyloxyethyl phosphorylcholine) (PMPC) is a methacrylate based polymer with a zwitterionic phosphorylcholine moiety on the side chain. The phosphorylcholine moiety is very similar to the head group of phospholipids in cell membranes. Due to this unique structure, PMPC showed excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation, as well as cell membrane penetration and underwater lubrication.


PMPC has been widely exploited in a diverse range of applications including
  • antifouling materials for water treatment
  • bioengineering
  • nanomedicine

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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An introduction to zwitterionic polymer behavior and applications in solution and at surfaces.
Blackman L D, et al.
Chemical Society Reviews, 48, 757-757 (2019)
Andrew Lewis et al.
Bioconjugate chemistry, 19(11), 2144-2155 (2008-11-01)
The water-soluble, biocompatible polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was evaluated for protein conjugation. PMPC is a zwitterionic polymer that is able to form a more compact conformation in aqueous solution than poly(ethylene glycol) (PEG). While a terminally functionalized N-hydroxysuccinimide derivative of

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