933899
N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride
degree of quaternization 50%
Synonym(s):
Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan
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About This Item
Linear Formula:
(C12H25N2O5Cl)n(C8H13NO5)m
UNSPSC Code:
12352201
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description
NMR: Conforms to structure
Quality Level
form
(solid, chunks or fiber)
color
white to off-white
storage temp.
2-8°C
Related Categories
General description
Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.
The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications
The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications
Application
Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings
Tissue engineering
Antibacterial coatings
Features and Benefits
Water soluble
Cationically modified
Naturally derived and biocompatible
Cationically modified
Naturally derived and biocompatible
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for
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