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934232

Sigma-Aldrich

Pomalidomide-2,6-diazaspiro[3.3]heptane

≥95.0%

Synonym(s):

1H-Isoindole-1,3(2H)-dione, 5-(2,6-diazaspiro[3.3]hept-2-yl)-2-(2,6-dioxo-3-piperidinyl), 5-(2,6-Diazaspiro[3.3]heptan-2-yl)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione

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About This Item

Empirical Formula (Hill Notation):
C18H18N4O4
CAS Number:
2226301-50-2
Molecular Weight:
354.36
UNSPSC Code:
12352200
NACRES:
NA.21

ligand

pomalidomide

Quality Level

100

assay

≥95.0%

form

powder or crystals

color

off-white to light yellow

storage temp.

2-8°C

SMILES string

O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CC5(CNC5)C4)C=C31)=O

Application

Pomalidomide-2,6-diazaspiro[3.3]heptane Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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