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936561

Sigma-Aldrich

(S,R,S)-AHPC-CO-PEG1-C2-acid

≥95%

Synonym(s):

3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl) pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid, 3-[3-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propanoic acid

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About This Item

Empirical Formula (Hill Notation):
C28H38N4O7S
CAS Number:
Molecular Weight:
574.69
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.21

ligand

VH032

Quality Level

assay

≥95%

form

powder or crystals

color

white to light yellow

storage temp.

2-8°C

SMILES string

C([C@@H](NC(CCOCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Application

(S,R,S)-AHPC-CO-PEG1-C2-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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