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F5062

Sigma-Aldrich

Fmoc-Lys(Me)3-OH Chloride

≥97%, for peptide synthesis

Synonym(s):

Fmoc-Lys(Me3Cl)-OH, N-alpha-Fmoc-N-alpha-trimethyl-N-L-lysine · chloride

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About This Item

Empirical Formula (Hill Notation):
C24H31ClN2O4
CAS Number:
201004-29-7
Molecular Weight:
446.97
UNSPSC Code:
12352209
NACRES:
NA.26

product name

Fmoc-Lys(Me)3-OH Chloride, ≥97%

Quality Level

100

assay

≥97%

form

liquid

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

functional group

Fmoc

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1

InChI key

XUJRNPVABVHOAJ-FTBISJDPSA-N

Related Categories

General description

Fmoc protected N-trimethyl lysine

Application

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:
  • Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.
  • Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.
  • Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Multifunctional Reagents for Quantitative Proteome?Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development.
Broncel M, et al.
Angewandte Chemie (International Edition in English), 54(20), 5948-5951 (2015)
Novel peptide linkers for highly potent antibody? auristatin conjugate.
Doronina S O, et al.
Bioconjugate Chemistry, 19(10), 1960-1963 (2008)
Sequential Peptide Ligation by Combining the Cys?Pro Ester (CPE) and Thioester Methods and Its Application to the Synthesis of Histone H3 Containing a Trimethyl Lysine Residue.
Kawakami T, et al.
Bulletin of the Chemical Society of Japan, 86(6), 690-697 (2013)

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