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M2780

Sigma-Aldrich

N6-Methyladenosine 5′-monophosphate sodium salt

≥97% (HPLC)

Synonym(s):

6-Me-5′-AMP, N-Methyl-5′-adenylic acid disodium salt

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About This Item

Linear Formula:
C11H15N5O7PNa
CAS Number:
81921-35-9
Molecular Weight:
383.23
UNSPSC Code:
41106305
PubChem Substance ID:
24896766

Quality Level

200

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

[Na].CNc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(O)C3O

InChI

1S/C11H16N5O7P.2Na/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(23-11)2-22-24(19,20)21;;/h3-5,7-8,11,17-18H,2H2,1H3,(H,12,13,14)(H2,19,20,21);;/q;2*+1/p-2/t5-,7-,8-,11-;;/m1../s1

InChI key

HFOKUKRAZPHTHH-LYYWGVPGSA-L

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Application

N6-Methyladenosine 5′-monophosphate sodium salt can be used in N6-methyladenosine (m6A) ribonucleoprotein immunoprecipitation reactions. m6A has gained a lot of attention in the recent years because the mRNA modification with m6A has been shown to play a role in stability and translational efficiency of mRNA.

Biochem/physiol Actions

A glycogen phosphorylase b activator.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.
Fry N J, et al.
RNA, 23(9), 1444-1455 (2017)
N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Wang X, et al.
Cell, 161(6), 1388-1399 (2015)
M Morange et al.
European journal of biochemistry, 65(2), 553-563 (1976-06-01)
A series of AMP analogs has been selected in order to better understand the structural requirements (a) for the efficient binding of the activator molecule at the correct site on phosphorylase b from rabbit skeletal muscle and (b) for the
Fengchao Lang et al.
PLoS pathogens, 15(6), e1007796-e1007796 (2019-06-22)
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV
Ki-Jun Yoon et al.
Cell, 171(4), 877-889 (2017-10-03)
N
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