QBD10184
dPEG®8-SATA (S-acetyl-dPEG®8-NHS ester)
Synonym(s):
Polyethylene glycol
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About This Item
Empirical Formula (Hill Notation):
C25H43NO13S
CAS Number:
Molecular Weight:
597.67
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
assay
>90%
form
solid or viscous liquid
reaction suitability
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: amine reactive
polymer architecture
shape: linear
functionality: monofunctional
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O
Related Categories
Features and Benefits
dPEG®8-SATA (S-acetyl-dPEG®8-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG®8-SATA to install a protected thiol connected to the molecule via the dPEG® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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