700146P
Avanti
alkyne-cholesterol
27-norcholest-5-en-25-yn-3β-ol, powder
Synonym(s):
alkynyl cholesterol
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About This Item
Empirical Formula (Hill Notation):
C26H40O
CAS Number:
Molecular Weight:
368.60
UNSPSC Code:
12352211
Recommended Products
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (700146P-100ug)
pkg of 1 × 250 μg (700146P-250ug)
manufacturer/tradename
Avanti Polar Lipids 700146P
lipid type
click reagents
shipped in
dry ice
storage temp.
−20°C
Related Categories
General description
Alkyne-cholesterol is a clickable cholesterol probe proprietary for Avanti Polar Lipids. They differ from cholesterol by having an alkyne group.
This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry′, in the presence of a copper (Cu)-containing catalyst.
Biochem/physiol Actions
Alkyne-cholesterol is not applicable for use in living cells due to copper ion (Cu (I) and Cu (II)) requirements. It aids in easy and sensitive detection of cholesterol using various biophysical methods. Alkyne-cholesterol can be conjugated to boron-dipyrromethene (BODIPY) fluorescent dye. It is useful in cholesterol trafficking studies in various organelles including mitochondria, endoplasmic reticulum and Golgi.
Packaging
5 mL Amber Glass Screw Cap Vial (700146P-100ug)
5 mL Amber Glass Screw Cap Vial (700146P-250ug)
Storage Class
11 - Combustible Solids
Certificates of Analysis (COA)
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Katherine Windsor et al.
Journal of lipid research, 54(10), 2842-2850 (2013-07-06)
Lipid modifications aid in regulating (and misregulating) protein function and localization. However, efficient methods to screen for a lipid's ability to modify proteins are not readily available. We present a strategy to identify protein-reactive lipids and apply it to a
J Králová et al.
Folia biologica, 65(1), 1-10 (2019-06-07)
Cellular cholesterol plays fundamental and diverse roles in many biological processes and affects the pathology of various diseases. Comprehensive and detailed understanding of the cellular functions and characteristics of cholesterol requires visualization of its subcellular distribution, which can be achieved
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