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B-067

Supelco

(±)-Baclofen-D4 solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C10H8D4ClNO2
Molecular Weight:
217.69
MDL number:
MFCD21363459
UNSPSC Code:
41116107
PubChem Substance ID:
329773124
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

Related Categories

General description

Baclofen, a derivative of gamma-aminobutyric acid (GABA), is a muscle relaxant used to treat spasticity. Marketed with brand names such as Kemstro, Lioresal or Gablofen, the drug has also shown effectiveness in the treatment of alcoholism. This certified solution standard is suitable for use as an internal standard in quantitative mass spectrometry-based testing applications in clinical toxicology, forensic analysis, pharmaceutical research or diagnostic testing.

Application


  • Antidepressant Efficacy in Psychotherapy: Analyzes the effectiveness of combining antidepressants like O-Desmethylvenlafaxine with psychotherapy, enhancing therapeutic strategies for depression treatment (Alemi et al., 2024).

  • Advanced Quantification Methods: Development of a multiplexed liquid chromatography-tandem mass spectrometry method for the quantification of Venlafaxine and its metabolites, including O-Desmethylvenlafaxine, crucial for precise pharmacokinetic studies in clinical settings (Pandey et al., 2024).

  • Pharmacokinetic Modeling: Utilizes physiologically based pharmacokinetic modeling to explore the impact of CYP2D6 and CYP2C19 polymorphisms on Venlafaxine metabolism, crucial for understanding the role of O-Desmethylvenlafaxine in therapeutic efficacy and drug-gene interactions (Shen et al., 2024).

  • Impact of Pharmacogenomics: Studies the influence of CYP2D6 phenotype on the pharmacokinetics of Venlafaxine in elderly patients, highlighting the importance of O-Desmethylvenlafaxine levels in optimizing antidepressant dosing (Men et al., 2024).

  • Environmental Monitoring: Investigates the presence of pharmaceuticals, including O-Desmethylvenlafaxine, in surface waters under the EU Water Framework Directive, emphasizing the need for robust environmental surveillance and pollution control measures (Colzani et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Description
Pricing

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

wgk_germany

WGK 2

flash_point_f

closed cup

flash_point_c

closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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