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B-901

Supelco

Buprenorphine-D4 solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C29H37NO4D4
CAS Number:
Molecular Weight:
471.66
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal)

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

2-8°C

SMILES string

[2H]C1([2H])CC1C([2H])([2H])N2CC[C@]34[C@H]5Oc6c(O)ccc(C[C@@H]2[C@]37CC[C@@]5(OC)[C@H](C7)[C@](C)(O)C(C)(C)C)c46

InChI

1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1/i6D2,16D2/t17?,20-,21-,24-,26+,27-,28+,29-

InChI key

RMRJXGBAOAMLHD-UHGBJPCQSA-N

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General description

An internal standard suitable for buprenorphine testing or isotope dilution methods by GC/MS or LC/MS for clinical toxicology, pain prescription monitoring, urine drug testing, or forensic analysis. Buprenorphine is a semi-synthetic opiate used in the treatment of moderate acute pain and opioid addiction. The drug is sold under numerous trade names such as Suboxone®, Subutex®, and Temgesic.

Application


  • Determination of buprenorphine and norbuprenorphine in urine and hair by gas chromatography-mass spectrometry - This pivotal study utilizes Buprenorphine-D₄ as an internal standard to enhance the analytical accuracy of buprenorphine and its metabolite norbuprenorphine in biological samples, crucial for opioid pharmacokinetics study and drug monitoring (Vincent et al., 1999).

  • HPLC-MS for the determination of sildenafil citrate (Viagra) in biological fluids. Application to the salivary excretion of sildenafil after oral intake - Although this study primarily focuses on sildenafil, the methodology involving high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) where Buprenorphine-D₄ can be utilized as an internal standard demonstrates its broader application potential in drug metabolism and pharmacokinetic research, especially in studies involving complex biological matrices (Tracqui et al., 2003).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Suboxone is a registered trademark of RB Pharmaceuticals Limited
Subutex is a registered trademark of RB Pharmaceuticals Limited

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Description
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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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