E-070
Everolimus-D4 solution
100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
About This Item
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
100 μg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−70°C
SMILES string
[2H]C([2H])(O)C([2H])([2H])OC1CCC(CC(C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC(C)\C=C\C=C\C=C(C)\C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC)CC1OC
InChI
1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/i24D2,25D2
InChI key
HKVAMNSJSFKALM-ULVVDLMCSA-N
General description
Application
- Quantitative Bioanalysis in Therapeutic Drug Monitoring: Everolimus-D₄ is utilized as an internal standard in LC-MS/MS methods for the quantification of everolimus, highlighting its application in the pharmacokinetic studies of mTOR inhibitors. This method ensures accuracy and precision in therapeutic drug monitoring, crucial for optimizing dosages in cancer treatments and immunosuppressive therapies (Heideloff et al., 2013).
- Multi-Drug Analysis in Transplantation Medicine: The use of Everolimus-D₄ as a deuterated internal standard supports ultra-fast liquid chromatography-tandem mass spectrometry methods for simultaneously measuring multiple immunosuppressants in whole blood. This technique is vital for managing drug interactions and therapeutic levels in patients undergoing organ transplantation, which involves targeted therapy and mTOR inhibitors (Meinitzer et al., 2010).
Legal Information
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
wgk_germany
WGK 2
flash_point_f
closed cup
flash_point_c
closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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