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H-110

Supelco

Hydroxyitraconazole

100 μg/mL in methanol, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C35H38Cl2N8O5
CAS Number:
112559-91-8
Molecular Weight:
721.63
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

InChI

1S/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3

InChI key

ISJVOEOJQLKSJU-UHFFFAOYSA-N

Related Categories

General description

Hydroxyitraconazole is an active metabolite of itraconazole, an antifungal drug used for the treatment of fungal infections. Therapeutic drug monitoring of hydroxyitraconazole is utilized in the management of patients receiving itraconazole to ensure therapeutic levels of the drug have been achieved. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of hydroxyitraconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.

Application


  • Hydroxyitraconazole Antifungal Research: Utilized prominently in antifungal research, Hydroxyitraconazole serves as a potent inhibitor in studies targeting resistant fungal strains, contributing significantly to the development of more effective antifungal therapies (Krug et al., 2023).

  • Itraconazole Metabolite Study: As a major metabolite of itraconazole, Hydroxyitraconazole is crucial in pharmacokinetic studies to understand the metabolism of itraconazole, aiding in optimizing dosing for better therapeutic outcomes (Miljković et al., 2022).

  • Pharmaceutical Research Chemicals: This compound is pivotal in pharmaceutical research, providing insights into the drug′s behavior in biological systems and its interaction with other pharmacological agents, thereby facilitating drug development and safety evaluations (Iwasaki et al., 2019).

  • Antifungal Drug Discovery: Integral to antifungal drug discovery, Hydroxyitraconazole aids in screening and developing new drug candidates, especially those targeting difficult-to-treat infections, thus expanding the arsenal against global fungal threats (Müller et al., 2017).



Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

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