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L-029

Supelco

Lacosamide solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C13H18N2O3
CAS Number:
175481-36-4
Molecular Weight:
250.29
MDL number:
MFCD08272557
UNSPSC Code:
41116107
PubChem Substance ID:
329817347
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CC(N[C@H](COC)C(NCC1=CC=CC=C1)=O)=O

InChI

1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1

InChI key

VPPJLAIAVCUEMN-GFCCVEGCSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Related Categories

General description

A Certified Spiking Solution® suitable for use in LC/MS or GC/MS applications in clinical toxicology, forensic analysis, urine drug testing, prescription monitoring or pharmaceutical research. Lacosamide is a new antiepileptic drug developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. The drug is marketed under the trade name Vimpat®.

Application


  • Lacosamide solution as a mass spectrometry standard: A recent development in analytical techniques features a UPLC-MS/MS method for determining lacosamide and its metabolites, essential for drug-drug interaction studies. This research underlines lacosamide′s role as a critical pharmaceutical research tool in the study of anti-epileptic drugs and their interactions (Chen et al., 2023).

  • Lacosamide as an anticonvulsant in pharmacological research: Investigations on the effects of chronic lacosamide on ovarian tissue in rats highlight the broader physiological impacts of long-term anti-seizure medication use. Such studies are critical for assessing the reproductive safety of anticonvulsants, informing guidelines for their use in women of childbearing age (Kart et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Vimpat is a registered trademark of Harris FRC Corporation

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Molecule of the month. Lacosamide.
Drug news & perspectives, 17(10), 689-689 (2005-02-08)
G McCleane et al.
Neuroscience letters, 352(2), 117-120 (2003-11-20)
The aim of the study is to establish if the putative anticonvulsant SPM 927 has an analgesic effect in human neuropathic pain and to assess its tolerability. This is an open label study of 25 adult human subjects with resistant
Collin A Hovinga
IDrugs : the investigational drugs journal, 6(5), 479-485 (2003-06-06)
Schwarz Pharma, under license from Harris FRC, is developing SPM-927, synthesized by researchers at the University of Houston, for the potential treatment of epilepsy and neuropathic pain.

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