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Sibutramine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Sibutramine hydrochloride monohydrate, 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil

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About This Item

Empirical Formula (Hill Notation):
C17H26ClN · HCl
CAS Number:
84485-00-7
Molecular Weight:
316.31
EC Number:
200-659-6
MDL number:
MFCD04039806
UNSPSC Code:
41116107
PubChem Substance ID:
329824413
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

InChI

1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

InChI key

KFNNPQDSPLWLCX-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

Related Categories

General description

Sibutramine, a SNRI and anorectant, was marketed as a treatment for obesity until 2010 when it was removed from the market over concerns of potential adverse cardiovascular side effects. Sold under trade names Reductil, Meridia®, and Subitrex, this sibutramine Snap-N-Spike® reference solution is applicable for use in LC/MS or GC/MS applications for clinical toxicology and forensic analysis.

Biochem/physiol Actions

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Meridia is a registered trademark of Abbott Laboratories Corp.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V

Separation of Sibutramine hydrochloride monohydrate, ≥98% (HPLC), solid

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