Skip to Content
MilliporeSigma
All Photos(1)

Documents

T-041

Supelco

Topiramate-D12 solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C12D12H9NO8S
CAS Number:
Molecular Weight:
351.44
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

[2H]C([2H])([2H])C1(O[C@H]2CO[C@@]3(COS(N)(=O)=O)OC(O[C@H]3[C@H]2O1)(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])([2H])[2H]

InChI

1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7?,8?,9-,12-/m0/s1/i1D3,2D3,3D3,4D3

InChI key

KJADKKWYZYXHBB-FTZSVORRSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Suitable uses for this certified solution standard include as an internal standard for quantitation of topiramate levels in biological matrices such as urine or isotope dilution methods by LC/MS or GC/MS for clinical toxicology, urine drug testing, or forensic analysis applications. Topiramate, sold under trade name Topamax®, is an antiepileptic drug used for the treatment of seizures. Topiramate in combination with the stimulant phentermine constitute the active compounds in the new weight lose drug Qsymia®.

Application


  • Quantitative determination of topiramate in human plasma: A method employing liquid chromatography tandem mass spectrometry was developed to quantitatively determine topiramate in human plasma, highlighting the precision and applicability of using advanced analytical techniques for therapeutic drug monitoring in clinical settings (Popov et al., 2013).

  • Dried blood spots technique for topiramate: The development and validation of a dried blood spots technique for quantitative determination of topiramate using liquid chromatography-tandem mass spectrometry was conducted. This method offers a minimally invasive sample collection option that could improve therapeutic drug monitoring for patients on topiramate (Popov et al., 2013).

  • Therapeutic drug monitoring by LC-MS/MS: A study described a robust method for the therapeutic drug monitoring of topiramate using liquid chromatography-tandem mass spectrometry (LC-MS/MS), providing essential data on drug stability and concentration levels necessary for effective patient management (Matar, 2010).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Qsymia is a registered trademark of Vivus, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Topamax is a registered trademark of Johnson & Johnson

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 9

1 of 9

Topiramate United States Pharmacopeia (USP) Reference Standard

USP

1672206

Topiramate

Valproic Acid-D6 solution 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-029

Valproic Acid-D6 solution

Pregabalin-D6 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

P-096

Pregabalin-D6 solution

Midazolam-d4 maleate 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

M-918

Midazolam-d4 maleate

Topiramate ≥98% (HPLC), solid

Sigma-Aldrich

T0575

Topiramate

Levetiracetam solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

L-020

Levetiracetam solution

Lamotrigine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1392

Lamotrigine

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service