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05-1134

Sigma-Aldrich

Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1

clone VBS1, from mouse

Synonym(s):

CD331 antigen, Fms-like tyrosine kinase 2, basic fibroblast growth factor receptor 1, fibroblast growth factor receptor 1, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, soluble FGFR1 variant 1, soluble

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

VBS1, monoclonal

species reactivity

human, bovine, rat, chicken, mouse

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgM

NCBI accession no.

NP_001103677.1

UniProt accession no.

P11362

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FGF22(27006)

General description

The fibroblast growth factor receptors are members of the tyrosine kinase superfamily and consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. (Ornitz, DM. and Itoh, N) Monoclonal antibodies against the high affinity tyrosine kinase Fibroblast Growth Factor (FGF) receptor may help define receptor epitopes involved in FGF binding and signal transduction which mediate coronary and tumor angiogenesis. (Venkateswaran, S., et al).

Specificity

This antibody recognizes the extracellular ligand-binding domain of Fibroblast Growth Factor Receptor 1.

Immunogen

Epitope: Extracellular
FGF Receptor purified from bovine coronary venular endothelial cells.

Application

Detect Fibroblast Growth Factor Receptor 1 using this Anti-Fibroblast Growth Factor Receptor 1 Antibody, clone VBS1 validated for use in WB, IP, IH(P), ELISA.
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH(P) (Venkateswaran, S., et al)
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

Quality

Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: 0.78 µg/mL of this antibody detected Fibroblast Growth Factor Receptor 1 in 10 µg of NIH/3T3 cell lysate.

Target description

~92 kDa

Linkage

Replaces: MAB125

Physical form

Format: Purified
Purified mouse monoclonal IgM in 0.015 M potassium phosphate buffer containing 0.15 M NaCl, 0.1% sodium azide, pH 7.20.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
NIH/3T3 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A H Palamakumbura et al.
Oncogene, 28(38), 3390-3400 (2009-07-15)
Enhanced RAS signaling and decreased androgen dependence of prostate cancer cells accompany poor clinical outcomes. Elevated autocrine fibroblast growth factors 2 (FGF-2) signaling promotes prostate cancer cell growth and survival. Expression of lysyl oxidase (LOX) inhibits RAS transforming activity. LOX

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