05-903
Anti-GSK3α/β Antibody, rabbit monoclonal
Upstate®, from rabbit
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... GSK3A(2931)
Specificity
GSK3 alpha and beta
Predicted to cross-react with rat based on sequence homology
Immunogen
N-terminal 6His-tagged recombinant full length human GSK3β
Application
Anti-GSK3α/β Antibody is an antibody against GSK3α/β for use in IP & WB.
Quality
routinely evaluated by immunoblot on lysates from HEK293 cells
Target description
Mr 46kDa (beta) and 51kDa (alpha)
Physical form
Format: Purified
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Yasuhiro Nishino et al.
Circulation research, 103(3), 307-314 (2008-06-28)
The inactivation of glycogen synthase kinase-3beta (GSK-3beta) is proposed as the event integrating protective pathways initiated by preconditioning and other interventions. The inactivation of GSK-3 is thought to decrease the probability of opening of the mitochondrial permeability transition pore. The
Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.
Chuluunbaatar, U; Roller, R; Feldman, ME; Brown, S; Shokat, KM; Mohr, I
Genes & Development null
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes.
Jope, Richard S
Trends in Pharmacological Sciences, 24, 441-443 (2003)
GSK-3: tricks of the trade for a multi-tasking kinase.
Doble, Bradley W and Woodgett, James R
Journal of Cell Science, 116, 1175-1186 (2003)
Jen Q Pan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(7), 1397-1411 (2011-03-11)
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