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06-676

Sigma-Aldrich

Anti-mGluR2/3 Antibody

Upstate®, from rabbit

Synonym(s):

Anti-GLUR2, Anti-MGLUR2, Anti-mGlu2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_000839
NM_000840

UniProt accession no.

Q14416

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

rat ... Grm2(24415)

Specificity

mGluR2 and mGluR3

Immunogen

peptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2

Application

Anti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot on rat brain microsomal preparation

Target description

100-110kDa

Physical form

0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol
Format: Purified
Protein A chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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L Emile et al.
Neuropharmacology, 35(5), 523-530 (1996-05-01)
Glutamic acid is the major excitatory amino acid of the central nervous system which interacts with two receptor families, the ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are coupled to G proteins and can be divided into
Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus.
Petralia, R S, et al.
The Journal of Comparative Neurology, 372, 356-383 (1996)
Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
Shigemoto, R, et al.
The Journal of Neuroscience, 17, 7503-7522 (1997)
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.
Dhanya, RP; Sheffler, DJ; Dahl, R; Davis, M; Lee, PS; Yang, L; Nickols, HH; Cho et al.
Journal of medicinal chemistry null
Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus.
Blumcke, I, et al.
Brain Research, 736, 217-226 (1996)
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