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07-356

Sigma-Aldrich

Anti-NR3A Antibody

Upstate®, from rabbit

Synonym(s):

Anti-GluN3A, Anti-NMDAR-L, Anti-NMDAR3A, Anti-NR3A

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIN3A(116443)

Specificity

NR3A

Immunogen

peptide corresponding to amino acids 1098-1113 (SRKTELEEYQKTNRTC) of rat NR3A

Application

Anti-NR3A Antibody is an antibody against NR3A for use in WB.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot in a rat brain microsomal protein preparation

Target description

130kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Hoau-Yan Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(35), 10961-10973 (2009-09-04)
Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble amyloid-beta (Abeta) can suppress synaptic activities by interacting with alpha7 nicotinic acetylcholine receptors (alpha7nAChRs). Here, we show that alpha7nAChR and NMDA
Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex.
Henson, MA; Roberts, AC; Salimi, K; Vadlamudi, S; Hamer, RM; Gilmore, JH; Jarskog, LF; Philpot, BD
Cerebral Cortex (1991)
Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting.
Mori, Hisashi and Mishina, Masayoshi
Life Sciences, 74, 329-336 (2003)
Amino terminal domain regulation of NMDA receptor function.
Herin, Greta Ann and Aizenman, Elias
European Journal of Pharmacology, 500, 101-111 (2004)
Region specific regulation of NR1 in rhesus monkeys following chronic antipsychotic drug administration.
O'Connor JA, Hasenkamp W, Horman BM, Muly EC, Hemby SE.
Biological Psychiatry null

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