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07-531

Sigma-Aldrich

Anti-PIR121-1/Sra-1 Antibody

Upstate®, from rabbit

Synonym(s):

Cytoplasmic FMR1-interacting protein 1, Specifically Rac1-associated protein 1, Sra-1, p140sra-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_014608

UniProt accession no.

Q7L576

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... CYFIP1(23191)
mouse ... Cyfip1(20430)

Specificity

PIR121-1/Sra-1 (aka CYFIP1)

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 872-886 (SQEFQRDKQPNAQPQ-C) of human PIR121-1/Sra-1, with a C-terminal cysteine added for conjugation purposes.

Application

Anti-PIR121-1/Sra-1 Antibody is an antibody against PIR121-1/Sra-1 for use in IP & WB.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Quality

routinely evaluated by immunoblot on RIPA homogenates from rat brain

Target description

Mr~130kDa

Physical form

Format: Purified
Protein A purified

Storage and Stability

stable 2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anika Steffen et al.
The EMBO journal, 23(4), 749-759 (2004-02-07)
The Rho-GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals to Scar/WAVE proteins leading to activation of Arp2/3-mediated actin polymerization. Scar/WAVE proteins do not interact with Rac1 directly, but instead assemble into multiprotein complexes, which was shown
Local F-actin network links synapse formation and axon branching.
Chia, PH; Chen, B; Li, P; Rosen, MK; Shen, K
Cell null
Patricia Kunda et al.
Current biology : CB, 13(21), 1867-1875 (2003-11-01)
In animal cells, GTPase signaling pathways are thought to generate cellular protrusions by modulating the activity of downstream actin-regulatory proteins. Although the molecular events linking activation of a GTPase to the formation of an actin-based process with a characteristic morphology
Marco A Salazar et al.
The Journal of biological chemistry, 278(49), 49031-49043 (2003-09-25)
Tuba is a novel scaffold protein that functions to bring together dynamin with actin regulatory proteins. It is concentrated at synapses in brain and binds dynamin selectively through four N-terminal Src homology-3 (SH3) domains. Tuba binds a variety of actin
Reply to "Reduced CYFIP2 Stability by Arg87 Variants Causing Human Neurological Disorders".
Mitsuko Nakashima et al.
Annals of neurology, 86(5), 805-806 (2019-09-12)
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